CMCC 1091

Continuous Glucose Monitor for Infants on ECMO

Inventors: Michael Agus

Categories: Medical Device

SubCategories: Endocrinology

Keywords:

Invention Description:

Recent evidence has demonstrated that strict glycemic control improves morbidity and mortality in critically ill patients. Clinical glycemic control strategies are now being implemented in the adult and pediatric intensive care unit. To date, there is no data on the use continuous glucose monitoring techniques in critically ill infants. The Extracorporeal Glucose Monitoring System (EGMS) has recently been developed to measure live, continuous glucose levels in an extracorporeal blood circuit. The EGMS includes an electrochemical sensor enclosed in a 7.5-French silicone catheter that measures serum glucose concentration every minute using glucose oxidase. Following cannulation, EGMS sensors are inserted using sterile technique via adaptor tubing into the venous return limb of the circuit. Sensor readings are transmitted telemetrically at 900 MHz to an adjacent computer. Sensors are calibrated with three laboratory glucose values within two hours of insertion and then every 24 hours.

Applications:

Clinical research involves giving insulin to babies on extracorporeal membrane oxygenation (ECMO) to suppress/decrease loss of muscle mass/protein. Hence it is necessary to monitor glucose continuously. A pilot study was carried out and reported the first clinical use of EGMS for live continuous glucose monitoring in critically ill infants on ECMO and EGMS measurement were found to be clinically accurate compared to reference glucose measurements. Generally, the trend towards strict glycemic control in the intensive care unit has created a need for glucose monitoring techniques that are both highly accurate and readily attainable, making the EGMS a highly valuable tool in the (neonatal) ICU.

Competitive Advantages:

Business Opportunity:

Exclusive license

Key Publications: WO 2005/044088 A2

IPStatus: Pat. Pend.